Platelets have proven therapeutic utility for a variety of clinical diagnoses. Extended platelet storage allows hospitals and blood banks to greatly enhance the scope and quality of the services they provide. In addition, CPT stored platelets remain in circulation long after transfusion and retain long-term hemostatic ability.
Platelet Storage Implications
The implications of this technological breakthrough for the storage of platelet are:
- Reduction of Safety Risks
Refrigeration of platelets inhibits bacterial growth and ensures contamination does not occur in the storage process. Longer storage also allows for a more rigorous testing process of samples.
- Alleviate Global Platelet Supply Shortages
Longer shelf-life of platelets allows greater flexibility to respond to fluctuating global demand for platelets.
- Expand Existing Distribution Networks
Longer storage time and instrument design facilitate the transportation of platelets by increasing the ease and allowable duration of transportation.
CPT Platelet Storage Technology
CPT's unique approach extends storage of platelets by addressing both the risk of bacterial growth and the degradation of platelet functionality during storage. This platelet storage technology utilizes a combination of optimal levels of temperature, pressure and xenon gas concentration in order to ensure the integrity and reliability of the platelets for use after storage.
CPT's novel application of xenon gas is a key component of this breakthrough technology. By taking advantage of xenon's unique qualities as an inert gas and its non-toxicity at controlled levels, CPT technology creates an environment conducive to refrigeration and long-term storage, while simultaneously preserving the functional and morphological characteristics of the platelets. Storage in a hyperbaric Xe atmosphere has been proven to prevent immediate clearance of platelets from the blood stream upon transfusion. By remaining in circulation, stored platelets have long-term hemostatic functionality.
Refrigeration of platelets prevents bacterial growth in stored samples, thereby addressing the contamination concerns that currently limit the allowable length of platelet storage. Refrigeration has also been shown to effectively slow down cell metabolism and inhibit cell death pathways within the cell. This allows extended storage of platelets while maintaining their functional integrity.